反応 #10519

反応方程式

(2S,5S)-5-(2-benzylamino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

hydrogen

→

(2S,5S)-5-(2-amino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester hydrogen acetate

溶媒

acetic acid

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off through kieselguhr
2. 2
   洗浄the filter cake was washed with 20 ml of acetic acid
3. 3
   濃縮The combined organic phases were concentrated in vacuo
4. 4
   その他The crude product was employed without further purification in the next reaction

実験手順

1600 mg of (2S,5S)-5-(2-benzylamino-2-carboxyethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester were dissolved in 30 ml of acetic acid. 100 mg of 20% palladium hydroxide on activated carbon were added thereto, and the mixture was hydrogenated under an atmosphere of 1 bar of hydrogen for 1 h. Ar was then passed over the solution for 10 min. The catalyst was filtered off through kieselguhr and the filter cake was washed with 20 ml of acetic acid. The combined organic phases were concentrated in vacuo. The crude product was employed without further purification in the next reaction.

出典