反応 #10501

反応方程式

acrylic acid

2-amino-4-bromo-phenol

methanesulfonic acid

phosphorus pentoxide

NaOH

→

5-bromo-2-vinyl-benzooxazole

収率 45.1%

溶媒

water

dichloromethane

diethyl ether

—

ice

water

反応条件

後処理

1. 1
   workup.STIRRINGTo this well stirred suspension
2. 2
   温度cooled to room temperature
3. 3
   workup.ADDITIONThe mixture was then poured into a separatory funnel
4. 4
   workup.STIRRINGshaken vigorously
5. 5
   その他A small quantity of solid was removed by suction filtration
6. 6
   workup.STIRRINGthe filtrate again shaken vigorously in a separatory funnel
7. 7
   その他The organic phase was collected
8. 8
   乾燥dried over Na2SO4
9. 9
   濃縮concentrated in vacuo to a thick syrup
10. 10
    その他that crystallized
11. 11
    その他to give large yellow stars
12. 12
    その他Purification by flash chromatography on silica gel (eluting with 1:1 hexane:dichloromethane)

実験手順

A mixture of 12 g of methanesulfonic acid and 1.8 g of phosphorus pentoxide (P2O5) was stirred 12 hours. To this well stirred suspension was added 0.346 g (4.8 mmol) of acrylic acid and 0.808 g (4 mmol) of 2-amino-4-bromo-phenol. The reaction was heated at 78° C. for 5 hours, then cooled to room temperature. The reaction was then slowly poured into a well-stirred slurry of 15 mL of 50% aqueous NaOH in 200 g of ice and water. The mixture was then poured into a separatory funnel and shaken with 300 mL water, 200 mL of diethyl ether, and 75 mL of dichloromethane and shaken vigorously. A small quantity of solid was removed by suction filtration, and the filtrate again shaken vigorously in a separatory funnel. The organic phase was collected, dried over Na2SO4, and concentrated in vacuo to a thick syrup that crystallized to give large yellow stars. Purification by flash chromatography on silica gel (eluting with 1:1 hexane:dichloromethane) gave 0.404 g (45%) of 5-bromo-2-vinyl-benzooxazole as a white powder, mp 55–56° C. 1H NMR (300 MHz, CDCl3) δ 7.84 (d, J=1.8 Hz, 1H), 7.46 (dd, J=8.7, 1.8 Hz, 1 H), 7.40 (d, J=8.7 Hz, 1 H), 6.76 (dd, J=17, 10.5 Hz, 1 H), 6.50 (d, J=17 Hz, 1 H), 5.90 (d, J=10.5 Hz, 1 H); Mass spectrum: [M+H]+ at 224.0 & 226.0.

出典