反応 #1049540

反応方程式

N,N'-dicyclohexyl-carbodiimide

4-(5-octyl-pyrimidin-2-yl)-benzoic acid

cyclopentane-hexanol

→

6-cyclopentyl-hexyl 4-(5-octyl-pyrimidin-2-yl)-benzoate

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮concentrated
3. 3
   その他The residue is chromatographed on 10 g of silica gel with hexane/ethyl acetate 19:1 (v/v)
4. 4
   その他Recrystallization of the product-containing fractions from ethanol

実験手順

A solution of 0.3 g of N,N'-dicyclohexyl-carbodiimide in 6 ml of dichloromethane is added dropwise at 0° C. within 15 minutes to a solution of 0.201 g of 4-(5-octyl-pyrimidin-2-yl)-benzoic acid, 0.116 g of cyclopentane-hexanol and 0.02 g of 4-dimethylaminopyridine in 10 ml of dichloromethane. The suspension is stirred at 0° C. for a further 1 hour, filtered and concentrated. The residue is chromatographed on 10 g of silica gel with hexane/ethyl acetate 19:1 (v/v). Recrystallization of the product-containing fractions from ethanol gives pure 6-cyclopentyl-hexyl 4-(5-octyl-pyrimidin-2-yl)-benzoate.

出典