反応 #1048

反応方程式

4-(4-fluorophenyl) methylaniline

bis(2-chloroethyl)amine hydrochloride

→

compound ( 5 )

収率 75.0%

1-[4-(4-fluorophenyl)methylphenyl]piperazine

収率 75.0%

反応条件

後処理

1. 1
   温度gradually raised in temperature to 200° C.
2. 2
   workup.STIRRINGfurther stirred for 2 hours
3. 3
   温度This was then cooled to room temperature
4. 4
   その他the product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5)

実験手順

A mixture of 500 mg of 4-(4-fluorophenyl) methylaniline and 445 mg of bis(2-chloroethyl)amine hydrochloride was stirred at 100° C. for 2 hours, then gradually raised in temperature to 200° C. and then further stirred for 2 hours. This was then cooled to room temperature, then the product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5) to obtain the above-referenced compound (5) in an amount of 503 mg (yield of 75%).

出典