反応 #10464

反応方程式

N-(aminocarbonothioyl)-3-chloro-2-methylbenzenesulfonamide

methyl 3-bromo-4-oxobutanoate

→

Methyl (2{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-5-yl)acetate

溶媒

pyridine

反応条件

後処理

1. 1
   その他were irradiated in a microwave oven for 2.5 min at 130° C
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   その他the product separated from the starting materials

実験手順

N-(aminocarbonothioyl)-3-chloro-2-methylbenzenesulfonamide (0.4 g, 1.5 mmol) and methyl 3-bromo-4-oxobutanoate (0.3 g, 1.5 mmol), dissolved in pyridine (5 mL), were irradiated in a microwave oven for 2.5 min at 130° C. The solvent was removed under reduced pressure and the product separated from the starting materials using preparative HPLC (yield 0.2 g, 30%).

出典