反応 #1044

反応方程式

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

収率 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

収率 94.2%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   ろ過filtered
3. 3
   その他The residue obtained
4. 4
   その他after evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   ろ過filtered
7. 7
   その他Evaporation of the solvent

実験手順

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

出典