反応 #1032

反応方程式

1-hydroxybenzotriazole

(S)-4-amino-5-chloro-2-[(1-methyl-2-butynyl)oxy]benzoic acid

8-amino-3-benzylazabicyclo[3.2.1]octane

WSC.HCl

→

title compound

(S)-N-(3-Benzyl-3-azabicyclo[3.2.1 ]oct-8-yl)-4-amino-5-chloro-2-(1-methyl-2-butynyl)oxybenzamide

反応条件

後処理

1. 1
   その他The product was purified by silica gel column chromatography (5% methanol/chloroform)

実験手順

The condensation of 530 mg of (S)-4-amino-5-chloro-2-[(1-methyl-2-butynyl)oxy]benzoic acid with 850 mg of 8-amino-3-benzylazabicyclo[3.2.1]octane was conducted in a similar manner to that of the Example 34 by the use of WSC.HCl and 1-hydroxybenzotriazole (HOBT). The product was purified by silica gel column chromatography (5% methanol/chloroform) to give 220 mg of the title compound.

出典