反応 #10267

反応方程式

NaOH

acetaldehyde

O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride

NaOH

→

2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime

収率 100.0%

溶媒

water

water

反応条件

後処理

1. 1
   抽出extracted with dichloromethane
2. 2
   乾燥The organic layer was dried (Na2SO4)
3. 3
   濃縮concentrated in vacuo

実験手順

A mixture of acetaldehyde (0.1 mL of a 50 wt % soln. in water), O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride (0.14 g), NaOH (2N, 0.64 mL) and water (5 mL) was stirred at room temperature overnight. The solution was made basic with NaOH (1N) and extracted with dichloromethane. The organic layer was dried (Na2SO4), and concentrated in vacuo to afford 2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime (0.13 g, ˜100%), which was used as such.

出典