反応 #10215

ord-6961669486c8494bb2c3a3bdd60048e7

反応方程式

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid
→
CC(O)C(=O)O.NC(=O)c1ccncc1
Isonicotinic Acid Amide Lactic Acid

反応物

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid

試薬

なし

溶媒

O
water
O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.DISSOLUTIONto dissolve them
  2. 2
    workup.ADDITIONwas added
  3. 3
    その他a kinematic viscosity at room temperature of 0.95 centistokes was obtained

実験手順

To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07094414B2uspto-grants-2006_08