反応 #1017533

反応方程式

N-((4S,6S)-4-(6-bromo-3-fluoropyridin-2-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide

intermediate 32

4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide

→

title compound

N-(6-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide

反応条件

実験手順

The title compound was synthesized by procedures and steps analogous to those described in Method R, Example 134 above, except N-((4S,6S)-4-(6-bromo-3-fluoropyridin-2-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide (11i) underwent the conditions described in step 10 with 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide (intermediate 32) followed by the conditions described in step 9. MS m/z=488.9 [M+H]+. Calculated for C16H12ClF7N6O2: 488.1.

出典