反応 #1005985

反応方程式

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

収率 92.0%

溶媒

acetone

反応条件

後処理

1. 1
   その他Reaction
2. 2
   ろ過filtered through celite
3. 3
   濃縮Filtrate was concentrated on Rotavapor under vacuum
4. 4
   その他the crude residue was purified on SiO2 using Biotage SP1

実験手順

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

出典