反応 #1005983

反応方程式

Compound 47

N-(4-chlorobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

tetra-n-butylammonium azide

→

N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

溶媒

acetone

反応条件

後処理

1. 1
   温度the reaction was refluxed for 8 h
2. 2
   その他solvent was evaporated on Rotavapor
3. 3
   その他to give a crude compound which
4. 4
   その他on purification by Biotage SP1

実験手順

Compound 47 (4.3) (1 mmol) was taken in anhydrous acetone (25 mL) and tetra-n-butylammonium azide (2 mmol) was added and the reaction was refluxed for 8 h. The reaction was cooled to RT and solvent was evaporated on Rotavapor to give a crude compound which on purification by Biotage SP1 provided pure N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide (48/4.4).

出典