反応 #1005981

反応方程式

1,4-dimethylsulphonyl-2-butene

4-methoxybenzylamine

→

product

収率 63.6%

1-(4-methoxybenzyl)-3-pyrroline

収率 63.6%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The solid was filtrated
2. 2
   洗浄the filtrate was washed with water (2×30 ml)
3. 3
   乾燥dried over Na2SO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated
6. 6
   その他The crude was purified by flash chromatography

実験手順

To a solution of 1,4-dimethylsulphonyl-2-butene (2.15 g, 11.64 mmol) in dichloromethane (40 ml), 4-methoxybenzylamine (6 ml, 44.24 mmol) was added dropwise and the solution was stirred 20 hours at r.t. The solid was filtrated and the filtrate was washed with water (2×30 ml), dried over Na2SO4, filtered and concentrated. The crude was purified by flash chromatography: silica gel, gradient hexane:ethyl acetate 3:1 to 1:1. to afforded the product (1.4 g, 63%) as yellow oil.

出典