反応 #1005969

反応方程式

3-chloroperoxybenzoic acid

2-(2-ethylsulfanyl-4-trifluoromethylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine

sodium thiosulfate

→

2-(2-ethylsulfonyl-4-trifluoromethylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine

溶媒

chloroform

反応条件

後処理

1. 1
   抽出the mixture was extracted with chloroform
2. 2
   洗浄The organic layer was washed with a saturated aqueous sodium bicarbonate solution
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure

実験手順

436 mg of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 236 mg of 2-(2-ethylsulfanyl-4-trifluoromethylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine and 5 ml of chloroform under ice cooling, and the mixture was stirred at room temperature for 4 hours. A 10% aqueous sodium thiosulfate solution was poured to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous magnesium sulfate, then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 122 mg of 2-(2-ethylsulfonyl-4-trifluoromethylphenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridine (hereinafter, referred to as Compound of Present Invention 7).

出典