反応 #1005964

反応方程式

sodium bicarbonate

(2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide

phosphorus oxybromide

propionitrile

→

2-bromo-6-trifluoromethyl-imidazo[1,2-a]pyridine

収率 61.6%

反応条件

後処理

1. 1
   その他The cooled reaction mixture
2. 2
   ろ過a 5 M aqueous sodium hydroxide solution, and the precipitated solid was filtered
3. 3
   洗浄The resulting solid was washed with water and n-hexane

実験手順

A mixture of 1.63 g of (2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide, 2.84 g of phosphorus oxybromide and 2 ml of propionitrile was stirred at 100° C. for 2.5 hours. The cooled reaction mixture was neutralized in a saturated aqueous sodium bicarbonate solution and a 5 M aqueous sodium hydroxide solution, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane to obtain 808 mg of 2-bromo-6-trifluoromethyl-imidazo[1,2-a]pyridine.

出典