反応 #1005963

反応方程式

2-amino-5-trifluoromethylpyridine

bromoethylacetate

→

(2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide

反応条件

後処理

1. 1
   濃縮concentrated under reduced pressure
2. 2
   ろ過filtered
3. 3
   洗浄The resulting solid was washed with t-butyl methyl ether

実験手順

A mixture of 3.0 g of 2-amino-5-trifluoromethylpyridine and 7 ml of bromoethylacetate was stirred at 80° C. for 1 hour, and concentrated under reduced pressure. The resulting residue was suspended in a mixed solvent of acetonitrile and t-butyl methyl ether, and filtered. The resulting solid was washed with t-butyl methyl ether to obtain 2.46 g of (2-imino-5-trifluoromethyl-2H-pyridin-1-yl)ethyl acetate hydrobromide.

出典