反応 #1005957

反応方程式

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

収率 95.2%

溶媒

methanol

water

反応条件

後処理

1. 1
   抽出extracted twice with ethyl acetate
2. 2
   洗浄washed with water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   ろ過The desiccant was filtered
5. 5
   その他separated
6. 6
   その他the solvent was evaporated off under reduced pressure

実験手順

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

出典