反応 #1005944

反応方程式

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

収率 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

収率 42.5%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度After cooling the mixture to room temperature
2. 2
   洗浄washed with water three times
3. 3
   乾燥The organic layer was dried over anhydrous magnesium sulfate
4. 4
   その他The solvent was evaporated off under reduced pressure
5. 5
   その他the residue was then purified by a column chromatography

実験手順

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

出典