反応 #10051

反応方程式

water

1,8-Diazabicyclo[5,4,0]undec-7-ene

methyl-3-[(ethoxycarbonylamino)methyl]-2-(methoxycarbonyl)benzoate

aminoglutarimide hydrochloride

→

product

収率 46.8%

[2-(2,6-Dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-carbamic acid ethyl ester

収率 46.8%

溶媒

DMF

反応条件

後処理

1. 1
   温度The mixture was cooled to room temperature
2. 2
   抽出The mixture was extracted with ethyl acetate (3×30 ml)
3. 3
   洗浄the ethyl acetate solution was washed with water (30 ml), brine (30 ml)
4. 4
   その他dried
5. 5
   その他Solvent was removed
6. 6
   その他the residue was purified by flash chromatography (dichloromethane/ethyl acetate 7 to 3)

実験手順

1,8-Diazabicyclo[5,4,0]undec-7-ene (0.8 g, 5 mmol) was added to a stirred suspension of methyl-3-[(ethoxycarbonylamino)methyl]-2-(methoxycarbonyl)benzoate (1.54 g, 5 mmol) and aminoglutarimide hydrochloride (0.86 g, 5 mmol) in DMF (15 ml). The mixture was heated to 120° C. for 24 hours. The mixture was cooled to room temperature and poured into water (150 ml). The mixture was extracted with ethyl acetate (3×30 ml) and the ethyl acetate solution was washed with water (30 ml), brine (30 ml) and dried. Solvent was removed and the residue was purified by flash chromatography (dichloromethane/ethyl acetate 7 to 3) to give 0.84 g (45%) of the product as a white solid: mp 187–189° C.; 1H NMR (DMSO-d6) δ 11.03 (s, 1H), 7.76–7.58 (m, 4H), 5.06–4.99 (dd, J=5.4 and 12.6 Hz, 1H), 4.52 (d, J=5.9 Hz, 2H), 3.91 (q, J=7.0 Hz, 2H), 2.79–2.70 (m, 1H), 2.51–2.38 (m, 2H), 1.96–1.86 (m, 1H), 1.06 (t, J=7.0 Hz, 3H); 13C NMR (DMSO-d6) δ 172.89, 169.93, 167.55, 167.05, 156.72, 139.69, 134.91, 132.90, 131.58, 127.04, 121.97, 60.15, 48.90, 39.34, 30.98, 22.04, 14.69; Anal. Calcd. For C17H17N3O6: C, 56.82; H, 4.77; N, 11.69. Found: C, 56.94; H, 4.81; N, 11.37.

出典