反応 #1001654

反応方程式

4-Methylbenzamide

1,3-dichloroacetone

→

title compound

収率 50.8%

4-(chloromethyl)-2-(4-methylphenyl)-1,3-oxazole

収率 50.8%

溶媒

ethanol

反応条件

後処理

1. 1
   温度the mixture was refluxed for 8 hr
2. 2
   温度After cooling
3. 3
   濃縮the reaction mixture was concentrated under reduced pressure
4. 4
   その他the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=10:1 to 7:1)

実験手順

4-Methylbenzamide (10.0 g) and 1,3-dichloroacetone (9.4 g) were dissolved in ethanol (100 mL), and the mixture was refluxed for 8 hr. After cooling, the reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=10:1 to 7:1) to give the title compound (7.8 g) as a white solid.

出典