反応 #10014

反応方程式

2,6-dichloro-purine

4-nitro-aniline

→

2-Chloro-6-(4-nitro-phenyl-amino)-purine

溶媒

DMF n-butanol

反応条件

後処理

1. 1
   その他the crystal mass which precipitates out
2. 2
   温度on cooling
3. 3
   ろ過is filtered off
4. 4
   その他dried in vacuo

実験手順

1.9 g (10 mmol) of 2,6-dichloro-purine are stirred in 40 ml of DMF/n-butanol (1:3) with 4.1 g (30 mmol) of 4-nitro-aniline at 130° C. for 24 h and the crystal mass which precipitates out on cooling is filtered off and dried in vacuo. 2-Chloro-6-(4-nitro-phenyl-amino)-purine is obtained; m.p.>270° C.; FAB-MS: (M+H)+=291; Rf=0.6 (CH2Cl2:methanol=9:1).

出典