反応 #10009

反応方程式

2-chloro-9-isopropyl-6-(3-fluoro-phenyl-amino)-9H-purine

ethanolamine

→

6-(3-fluoro-phenyl-amino)-2-(2-hydroxy-ethyl-amino)-9-isopropyl-9H-purine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度to cool
2. 2
   洗浄The organic phase is washed with water
3. 3
   乾燥dried over sodium sulfate

実験手順

0.2 g (0.63 mmol) of 2-chloro-9-isopropyl-6-(3-fluoro-phenyl-amino)-9H-purine (prepared according to Stage 91.1) is stirred in 1 ml of ethanolamine at 150° C. for 5 h, and the mixture is then allowed to cool and is diluted with ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. On concentration of the solvent, 6-(3-fluoro-phenyl-amino)-2-(2-hydroxy-ethyl-amino)-9-isopropyl-9H-purine is obtained as a crystalline mass. This is filtered off and dried; m.p. 142° C.; FAB-MS: (M+H)+=330; Rf=0.6 (CH2Cl2:methanol 9:1).

出典