反応 #10008

反応方程式

2-chloro-9-ethyl-6-(3-fluoro-phenyl-amino)-9H-purine

ethanolamine

→

2-(2-hydroxy-ethyl-amino)-6-(3-fluoro-phenyl-amino)-9-ethyl-9H-purine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度to cool
2. 2
   洗浄The organic phase is washed with water
3. 3
   その他separated off
4. 4
   乾燥dried over sodium sulfate
5. 5
   濃縮On concentration

実験手順

0.2 g (0.62 mmol) of 2-chloro-9-ethyl-6-(3-fluoro-phenyl-amino)-9H-purine (prepared according to Stage 90.2) is stirred in 1 ml of ethanolamine at 150° C. for 3 h, and the mixture is allowed to cool and is diluted with ethyl acetate. The organic phase is washed with water, separated off and dried over sodium sulfate. On concentration, 2-(2-hydroxy-ethyl-amino)-6-(3-fluoro-phenyl-amino)-9-ethyl-9H-purine is obtained as a crystalline precipitate. This precipitate is filtered off and dried; m.p. 184° C.; FAB-MS: (M+H)+=317; Rf=0.5 (CH2Cl2:methanol=9:1).

出典