CC(C)(C)C[C@@H]1N[C@@H](C(=O)NC2CCC(O)CC2)[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12

Reaction #419257

amine

収率 95.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C(N[C@H]1CC[C@H](O)CC1)[C@@H]1NC2(CC(CF)(CF)C2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F

Reaction #557860

title compound

収率 67.1%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #710518

amine

収率 95.0%DOI: 10.6084/m9.figshare.5104873.v1

CC(C)(C)C[C@@H]1N[C@H](C(=O)N[C@H]2CC[C@H](O)CC2)[C@@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12

Reaction #710520

(2′S,3R,4′R,5′S)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((trans)-4-hydroxy-cyclohexyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide

収率 39.3%DOI: 10.6084/m9.figshare.5104873.v1

CC(=O)OC1CCC(NC(=O)[C@H]2[C@H](c3cccc(Cl)c3F)[C@]3(C(=O)N(C(C)=O)c4cc(Cl)ccc43)[C@H](CC(C)(C)C)N2C(C)=O)CC1

Reaction #710521

Acetic acid 4-{[(2′S,3′R,4′S,5′R)-1,1′-diacetyl-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carbonyl]-amino}-cyclohexyl ester

DOI: 10.6084/m9.figshare.5104873.v1

CC(=O)N1[C@@H](CC(C)(C)C)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@@H](c2cccc(Cl)c2F)[C@@H]1C(=O)N[C@H]1CC[C@H](O)CC1

Reaction #710522

(2′S,3′R,4′S,5′R)-1′-acetyl-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carboxylic acid (trans-4-hydroxy-cyclohexyl)-amide

収率 89.5%DOI: 10.6084/m9.figshare.5104873.v1

CN1[C@@H](CC(C)(C)C)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@@H](c2cccc(Cl)c2F)[C@@H]1C(=O)NC1CCC(O)CC1

Reaction #710524

(2′S,3′R,4′S,5′R)-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-1′-methyl-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carboxylic acid (4-hydroxy-cyclohexyl)-amide

収率 33.1%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1279204

amine

収率 95.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1279206

(2′S,3R,4′R,5′S)-6-chloro-4′-(3-chloro-2-fluorophenyl)-N-((trans)-4-hydroxy-cyclohexyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide

収率 39.3%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1279207

(2′S,3′R,4′S,5′R)-1′-acetyl-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carboxylic acid (trans-4-hydroxy-cyclohexyl)-amide

収率 89.5%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1279209

(2′S,3′R,4′S,5′R)-6-chloro-4′-(3-chloro-2-fluoro-phenyl)-2′-(2,2-dimethyl-propyl)-1′-methyl-2-oxo-1,2-dihydro-spiro[indole-3,3′-pyrrolidine]-5′-carboxylic acid (4-hydroxy-cyclohexyl)-amide

収率 33.1%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1611803

amine

収率 95.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #1984154

amine

収率 95.0%DOI: 10.6084/m9.figshare.5104873.v1

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