#1041018

CC(C)(C)OC(=O)N(Cc1cc2c(cn1)OCCO2)C1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #221100
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
O=c1ccc2ncc(F)cc2n1CCN1CCC(CNCc2cc3c(cn2)OCCO3)C1
Reaction #285959
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #393238
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #472792
tert-butyl (1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate
収率 18.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02
O=C(N(Cc1cc2c(cn1)OCCO2)CC1CCCN(CCn2c(=O)ccc3ncc(F)cc32)C1)C(F)(F)F
Reaction #472845
N-(2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)-2,2,2-trifluoro-N-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-3-ylmethyl)acetamide
収率 92.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02
Cl.O=c1ccc2ncc(F)cc2n1CCN1CC[C@H](NCc2cc3c(cn2)OCCO3)C1
Reaction #472849
1-(2-((3S)-3-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)pyrrolidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one hydrochloride
収率 39.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02
O=c1ccc2ncc(F)cc2n1CCN1CCC(CNCc2cc3c(cn2)OCCO3)C1
Reaction #472852
1-(2-(3-(((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)methyl)pyrrolidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one
収率 14.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02
CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #744052
desired compound
収率 77.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_12
—
Reaction #744227
oil
収率 87.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_12
O=C(NCC1CN(CCn2c(=O)ccc3ncc(F)cc32)CC1O)OCc1ccccc1
Reaction #1032651
DOI: 10.1039/C8SC04228DValidation data from https://doi.org/10.1039/C8SC04228D
Cl
Reaction #1295929
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #1327605
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
CC(C)(C)OC(=O)NC1CCN(CCn2c(=O)ccc3ncc(F)cc32)CC1
Reaction #1597913
tert-butyl (1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate
収率 18.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07
O=C(N(Cc1cc2c(cn1)OCCO2)CC1CCCN(CCn2c(=O)ccc3ncc(F)cc32)C1)C(F)(F)F
Reaction #1597958
N-(2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)-2,2,2-trifluoro-N-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-3-ylmethyl)acetamide
収率 92.7%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07
Cl.O=c1ccc2ncc(F)cc2n1CCN1CC[C@H](NCc2cc3c(cn2)OCCO3)C1
Reaction #1597962
1-(2-((3S)-3-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)pyrrolidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one hydrochloride
収率 39.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07
O=c1ccc2ncc(F)cc2n1CCN1CCC(CNCc2cc3c(cn2)OCCO3)C1
Reaction #1597965
1-(2-(3-(((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)methyl)pyrrolidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one
収率 14.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07
O=C(N(Cc1cc2c(cn1)OCCO2)CC1CCCN(CCn2c(=O)ccc3ncc(F)cc32)C1)C(F)(F)F
Reaction #2405471
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (10/10)