Réaction #9969

Équation de réaction

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

4-formylpyridine

magnesium sulfate

→

title compound

Rendement 100.7%

(±)-7-(Pyridin-4-yl)methyleneamino-1,2,3,5,6,7,8,8a-octahydroindolizine

Rendement 100.7%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   FiltrationAt the end of this time, the reaction mixture was filtered
2. 2
   Autreto remove the catalyst
3. 3
   Concentrationthe filtrate was concentrated by evaporation under reduced pressure

Mode opératoire

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine (4.91 g (35.0 mmol), prepared as described in 1)) was dissolved in toluene (95 ml). To the solution were added 4-formylpyridine (3.34 ml, 35.0 mmol) and anhydrous magnesium sulfate (3.75 g, 31.2 mmol), and the resulting mixture was stirred at 70° C. for 3 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (8.08 g) as a pale yellow oil (yield quantitative).

Source