Réaction #992748

Équation de réaction

hydrochloric acid

2-bromo-4-nitro-6-trifluoromethyl-phenylamine

→

title compound

Rendement 99.2%

2-Bromo-6-trifluoromethyl-benzene-1,4-diamine

Rendement 99.2%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   workup.ADDITIONWater (100 mL) was added
3. 3
   Extractionthe mixture was extracted with ethyl acetate (2×100 mL)
4. 4
   LavageThe combined organic phases were washed with water (2×200 mL) and brine (200 mL)
5. 5
   Séchagedried over sodium sulfate
6. 6
   Concentrationconcentrated in vacuo

Mode opératoire

Aqueous hydrochloric acid (2 M, 45 mL) was added slowly to a mixture of zinc dust (8.6 g) and 2-bromo-4-nitro-6-trifluoromethyl-phenylamine (2.5 g) in tetrahydrofuran (50 mL). The reaction mixture was stirred for 1 hour, filtered and neutralized with saturated aqueous sodium bicarbonate (100 mL). Water (100 mL) was added and the mixture was extracted with ethyl acetate (2×100 mL). The combined organic phases were washed with water (2×200 mL) and brine (200 mL), dried over sodium sulfate and concentrated in vacuo to furnish 2.22 g (98% yield) of the title compound as a red solid. 1H NMR (500 MHz, DMSO-d6): 4.55 (s, 2H), 4.91 (s, 2H), 6.76 (d, 1H), 7.01 (d, 1H).

Source