Réaction #992706

Équation de réaction

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

Solvants

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

Conditions de réaction

Traitement

1. 1
   AutreIn a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   Autrethe solid was isolated by filtration
4. 4
   Autretwice recrystallized from isopropanol
5. 5
   LavageThe product was rinsed with isopropanol, suction
6. 6
   Autredried
7. 7
   Autrevacuum dried in an oven overnight

Mode opératoire

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

Source