Réaction #992693

ord-2ba0fedd47514f2ea231865f164fe779

Équation de réaction

O=C(O)CC(O)C(=O)O
DL-Malic acid
N=C(N)NN.O=C(O)O
Aminoguanidine bicarbonate
O=C=O
carbon dioxide
→
NNC(N)=[NH2+].NNC(N)=[NH2+].O=C([O-])CC(O)C(=O)[O-]
Bis(aminoguanidinium) DL-Malate

Réactifs

O=C(O)CC(O)C(=O)O
DL-Malic acid
N=C(N)NN.O=C(O)O
Aminoguanidine bicarbonate
O=C=O
carbon dioxide

Réactifs

Aucun

Solvants

O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe water was removed in vacuo
  2. 2
    Températurewith heating to approximately 90° C. for 4 hours
  3. 3
    AutreThe product was isolated as a white solid

Mode opératoire

DL-Malic acid (2.0 g, 14.92 mmol) was dissolved in 5 ml of distilled water. Aminoguanidine bicarbonate (4.06 g, 29.83 mmol) was added in portions at room temperature (carbon dioxide gas was evolved) and the reaction was stirred at room temperature for 18 hours. The water was removed in vacuo with heating to approximately 90° C. for 4 hours. The product was isolated as a white solid.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08012277B2uspto-grants-2011_09