Réaction #991154

Équation de réaction

Na2CO3

2-chloro-1-iodo-ethane

2-hydroxy-3-(2-methoxy-phenoxy)-3-phenyl-propylamine

NaH

→

2-[α-(2-methoxy-phenoxy)-benzyl]-morpholine

Rendement 57.0%

Solvants

ethyl acetate

water

dimethylformamide

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Températurethe whole was maintained at 50° C. for a further 3 hours

Mode opératoire

To a solution of 2-hydroxy-3-(2-methoxy-phenoxy)-3-phenyl-propylamine (10 g) in anhydrous dimethylformamide (150 ml), 55% NaH (1.75 g) was added at room temperature. After stirring for 1 hours, a solution of 2-chloro-1-iodo-ethane (7 g) in dimethylformamide (50 ml) was added all at one time. The temperature was maintained at 50° C. for 1 hour then Na2CO3 (5.82 g) was added and the whole was maintained at 50° C. for a further 3 hours. The whole was poured into water and extraction made with ethyl acetate. After a standard working up, procedure, 2-[α-(2-methoxy-phenoxy)-benzyl]-morpholine (6.24 g; 57%) was obtained as a transparent oil .HCl m.p. 140°-170° C.

Source