Réaction #987565

Équation de réaction

sulphamic acid

4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxycarbonylethyl)aniline

2-amino-5-nitrothiazole

propionic acid

Nitrosyl sulphuric acid

→

4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxy-carbonylethyl)aniline

Solvants

water

acetone

acetone

acetic acid

Conditions de réaction

Traitement

1. 1
   AutreAfter one hour the product was isolated by filtration
2. 2
   Lavagewashed with cold water
3. 3
   Autredried
4. 4
   Autreto yield

Mode opératoire

2-amino-5-nitrothiazole (2.9 parts) was set stirring at 5° C. with a mixture of acetic acid and propionic acid, 86:14 (50 parts). Nitrosyl sulphuric acid 40% (7.0 parts) was added below 5° C. and the mixture was stirred for 30 mins. The diazo solution was added gradually to a stirred coupling mixture of N-butyl, N-2(cyanomethoxycarbonylethyl)-aniline (5.2 parts), acetone (50 parts), water (200 parts) and sulphamic acid (0.5 parts). After one hour the product was isolated by filtration, washed with cold water and dried to yield, 4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxycarbonylethyl)aniline (2.9 parts) λmax=571 nm (acetone).

Source