Réaction #985249

Équation de réaction

acetyl chloride

neopentyl alcohol

1-methylimidazole

→

neopentyl acetate

Rendement 86.0%

Conditions de réaction

Traitement

1. 1
   AutreThe suspension which had formed in the meantime
2. 2
   AutreRemoval of the upper phase

Mode opératoire

6.47 g (82.5 mmol) of acetyl chloride were added dropwise with stirring at 20° C. to a solution of 6.61 g (75.0 mmol) of neopentyl alcohol (2,2-dimethyl-1-propanol) and 6.76 g (82.5 mmol) of 1-methylimidazole. The reaction mixture was stirred for a further 30 min and then heated to 75° C. The suspension which had formed in the meantime was converted to a liquid biphasic mixture. Removal of the upper phase gave 8.40 g (theory: 9.76 g) of neopentyl acetate as a colorless oil having a purity of 98% (GC).

Source