Réaction #9815

Équation de réaction

6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

hydrogen

→

title compound

Rendement 46.4%

6-Amino-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

Rendement 46.4%

Solvants

THF

MeOH

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Autrethe filtrate evaporated
3. 3
   Autrethe residue chromatographed on silica

Mode opératoire

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

Source