Réaction #981146

Équation de réaction

2-Cyanoaziridine

3,4-methylenedioxybenzoyl isocyanate

3,4-methylenedioxybenzamide

→

1-(N-3,4-Methylenedioxybenzoyl-carbamoyl)-2-cyanoaziridine

Solvants

toluene

toluene

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe reaction mixture is further stirred for 1 hour at 0° C.
2. 2
   Filtrationthe precipitated material (0.65 g.) is filtered off with suction at ambient temperature
3. 3
   Autreat 172° C. a clear melt is obtained)

Mode opératoire

0.26 g. 2-Cyanoaziridine are dissolved in 5 ml. toluene and introduced, while stirring at 0° C., into a solution of 0.73 g. 3,4-methylenedioxybenzoyl isocyanate in 25 ml. toluene. The reaction mixture is further stirred for 1 hour at 0° C. and the precipitated material (0.65 g.) is filtered off with suction at ambient temperature and briefly boiled with isopropanol, 0.2 g. of the desired 1-(N-3,4-methylenedioxybenzoyl-carbamoyl)-2-cyanoaziridine thereby remaining undissolved (m.p. 145°-153° C., at 172° C. a clear melt is obtained). It is contaminated with a little 3,4-methylenedioxybenzamide.

Source