Réaction #980995

Équation de réaction

N,N-bis(2-hydroxyethyl)-2-chloro-5-nitrobenzamide

potassium hydroxide

→

7-nitro-4-(2-hydroxyethyl)-2,3-dihydro-1,4-benzoxazepin-5-one

Rendement 66.5%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurewith reflux
2. 2
   Températurecooling
3. 3
   Filtrationthe precipitated, single-substance product is filtered off with suction
4. 4
   Autredried

Mode opératoire

144.5 g of N,N-bis(2-hydroxyethyl)-2-chloro-5-nitrobenzamide in 500 ml of water containing 28 g of potassium hydroxide are heated for 2 hours with reflux cooling. The mixture is cooled to 10° C. and the precipitated, single-substance product is filtered off with suction and dried. 84 g of 7-nitro-4-(2-hydroxyethyl)-2,3-dihydro-1,4-benzoxazepin-5-one of melting point 151° C. are obtained. ##STR22##

Source