Réaction #9750

Équation de réaction

water

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

intermediate 69

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

bromine

→

title compound

ethyl{4-[2-(5-bromothien-2-yl)ethoxy]-2-methylphenoxy}acetate

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Extractionthe resulting suspension extracted with diethyl ether
2. 2
   AutreThe organic layer was separated
3. 3
   Séchagedried over sodium sulfate
4. 4
   Concentrationconcentrated

Mode opératoire

A solution of ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate (intermediate 69, 0.306 g) in acetic acid (5 ml) was treated with bromine (0.180 g) at ambient temperature and the mixture stirred for 15 minutes. The mixture was poured into water and the resulting suspension extracted with diethyl ether. The organic layer was separated, dried over sodium sulfate and concentrated to give the title compound as a colourless oil.

Source