Réaction #973600

ord-883ae63113dd42e8a5fb337bbe5d8014

Équation de réaction

CN(C)C=NC(=O)c1cn2c(n1)-c1cnc(Cl)cc1OCC2
8-Chloro-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulene-2-carboxylic acid 1-dimethylamino-methylideneamide
Cl.NNC1CCCCC1
cyclohexylhydrazine hydrochloride
→
Clc1cc2c(cn1)-c1nc(-c3ncnn3C3CCCCC3)cn1CCO2
8-Chloro-2-(2-cyclohexyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulene

Réactifs

CN(C)C=NC(=O)c1cn2c(n1)-c1cnc(Cl)cc1OCC2
8-Chloro-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulene-2-carboxylic acid 1-dimethylamino-methylideneamide
Cl.NNC1CCCCC1
cyclohexylhydrazine hydrochloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Following the procedures of Example 378, 8-Chloro-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulene-2-carboxylic acid 1-dimethylamino-methylideneamide was reacted with cyclohexylhydrazine hydrochloride to give 8-Chloro-2-(2-cyclohexyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a,9-triaza-benzo[e]azulene (MS (ESI+) 371.2/373.2) which was reacted with L-prolineamide to give 409. MS (ESI+) 449.2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08242104B2uspto-grants-2012_08