Réaction #963810

Équation de réaction

2-iodophenol

3-hydroxy-3-methylbutyl tosylate

Cs2CO3

→

4-(2-iodophenoxy)-2-methylbutan-2-ol

Solvants

DMF

EtOAc

Conditions de réaction

Traitement

1. 1
   Lavagewashed with 1N HCl, saturated NaHCO3 aq., H2O, and brine
2. 2
   Séchagedried over anhydrous Na2SO4
3. 3
   AutreThe solvent was removed under reduced pressure
4. 4
   AutreThe resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3)
5. 5
   Autreto obtain compound aa28-1 (8.02 g) as pale yellow oil

Mode opératoire

A mixture of 2-iodophenol (6 g), 3-hydroxy-3-methylbutyl tosylate (7.4 g) and Cs2CO3 (13.3 g) in DMF (120 mL) was stirred at 0° C. for 2 h and at room temperature for 10 h. The mixture was diluted with EtOAc and washed with 1N HCl, saturated NaHCO3 aq., H2O, and brine, and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3) to obtain compound aa28-1 (8.02 g) as pale yellow oil.

Source