Réaction #96257

Équation de réaction

2-guanidino-4-chloromethylthiazole hydrochloride

3-Aminopropanethiol hydrochloride

sodium ethoxide

→

2-guanidino-4-[(3-aminopropyl)thiomethyl]thiazole hydrochloride

Solvants

ethanol

ethanol

Conditions de réaction

Traitement

1. 1
   Autreto reach room temperature
2. 2
   workup.STIRRINGstirred for 16 hours
3. 3
   FiltrationFiltration of the suspension and acidification of the filtrate with concentrated hydrochloric acid

Mode opératoire

3-Aminopropanethiol hydrochloride (2.54 g.) in ethanol (20 ml.) was added to a solution of sodium ethoxide (1 g. Na in 25 ml. ethanol) at 0° C. under a nitrogen atmosphere. The suspension was stirred at 0° C. for 2 hours and a solution of 2-guanidino-4-chloromethylthiazole hydrochloride (2.27 g.) in ethanol (25 ml.) was then added. The suspension was allowed to reach room temperature and stirred for 16 hours. Filtration of the suspension and acidification of the filtrate with concentrated hydrochloric acid gave a precipitate of 2-guanidino-4-[(3-aminopropyl)thiomethyl]thiazole hydrochloride, m.p. >350° C.

Source