Réaction #962

Équation de réaction

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

Rendement 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

Rendement 92.0%

Solvants

dimethyl sulfoxide

Conditions de réaction

Traitement

1. 1
   Extractionthe mixture was extracted three times with ethyl acetate
2. 2
   LavageThe combined organic layer was washed with brine
3. 3
   Séchagedried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Autreevaporated

Mode opératoire

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

Source