Réaction #96167

Équation de réaction

isopropyl 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

methanol

potassium carbonate

→

5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

Solvants

water

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture is refluxed under nitrogen atmosphere for 30 minitres
2. 2
   Températurecooled
3. 3
   Autreevaporated to dryness
4. 4
   Extractionof water and the resultant mixture extracted with ethyl acetate (2×50 ml.)
5. 5
   SéchageThe combined extracts are dried over magnesium sulfate
6. 6
   Autreevaporated to dryness under reduced pressure
7. 7
   AutreCrystallization of the residue from ethyl acetate-hexane

Mode opératoire

A solution of 336 mg. of isopropyl 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate in 10 ml. of methanol is treated with a solution of 690 mg. of potassium carbonate in 5 ml. of water. The reaction mixture is refluxed under nitrogen atmosphere for 30 minitres, cooled, and evaporated to dryness. The residue is taken up in 10 ml. of 10% aqueous hydrochloric acid and 50 ml. of water and the resultant mixture extracted with ethyl acetate (2×50 ml.). The combined extracts are dried over magnesium sulfate and evaporated to dryness under reduced pressure. Crystallization of the residue from ethyl acetate-hexane affords 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid.

Source