Réaction #96166

Équation de réaction

5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

hydrogen chloride

isopropanol

→

isopropyl 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

Conditions de réaction

Traitement

1. 1
   Températuremaintaining the temperature of the reaction mixture below 50° C
2. 2
   AutreThe ice bath is then removed
3. 3
   Autreevaporated to dryness under reduced pressure
4. 4
   workup.ADDITIONof benzene is added to the residue
5. 5
   Autrethe solution is evaporated under vacuum once again
6. 6
   Autreto completely remove the excess hydrogen chloride

Mode opératoire

A solution of 1.34 g. of 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 50 ml. of isopropanol, cooled in an ice bath is saturated with gaseous hydrogen chloride, maintaining the temperature of the reaction mixture below 50° C. The ice bath is then removed and the reaction mixture is stirred for 1.5 hours at room temperature, and evaporated to dryness under reduced pressure; 10 ml. of benzene is added to the residue and the solution is evaporated under vacuum once again, repeating this process a total of three times to completely remove the excess hydrogen chloride, thus obtaining of isopropyl 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate. The product is recrystallized from methanol-ethyl acetate.

Source