Réaction #96156

Équation de réaction

histamine H2

cysteamine

5-Dimethylaminomethyl-2-furanmethanol

2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamine

→

6-methyl-3-pyridylmethyl-4-pyrimidone

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températureby heating

Mode opératoire

5-Dimethylaminomethyl-2-furanmethanol can be converted into 2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamine by heating under reflux in acetic acid with cysteamine and can be further converted into various histamine H2 -antagonists for example, by reacting with a substituted pyrimidone to give 2-2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino-5-(6-methyl-3-pyridylmethyl-4-pyrimidone by methods described in EP 3677.

Source