Réaction #961
ord-1537debbdfcd4c9fb2d97af472b6fc7c
Équation de réaction
(3RS)-1-benzyl-3-hydroxymethyl pyrrolidine
thionyl chloride
→
(3RS)-1-benzyl-3-chloromethyl pyrrolidine
Réactifs
Aucun
Conditions de réaction
Conditions détaillées
See reaction.notes.procedure_details.
Traitement
- 1AutreThe mixture was evaporated
- 2workup.DISSOLUTIONthe residue was dissolved in water
Mode opératoire
To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.