Réaction #955955

Équation de réaction

acetic anhydride

butyl pyruvate

acetic anhydride

→

butyl α-acetoxyacrylate

Rendement 67.1%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   Autreto obtain a second reaction solution
3. 3
   Autrewas removed from the second reaction solution
4. 4
   workup.DISTILLATIONThereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.)

Mode opératoire

Next, in a mixture of the obtained butyl pyruvate (235 g, 1.6 mol) and acetic anhydride (333 g, 3.3 mol), p-toluenesulfonic acid monohydrate (5 g) was added. Then, the mixture was stirred under a nitrogen gas stream at 120° C. for 25 hours to obtain a second reaction solution. Next, acetic acid generated by a reaction with excess acetic anhydride under reduced pressure (5 mmHg) was removed from the second reaction solution. Thereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.) to obtain butyl α-acetoxyacrylate (200 g, yield 67%).

Source