Réaction #955938

Équation de réaction

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

Rendement 96.0%

Solvants

H2SO4

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed overnight
2. 2
   AutreMeOH was evaporated
3. 3
   Extractionthe residue was extracted to EtOAc
4. 4
   Lavagesuccessively washed with water and brine
5. 5
   Séchagedried over MgSO4
6. 6
   Filtrationfiltered
7. 7
   Autreevaporated

Mode opératoire

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

Source