Réaction #95438

Équation de réaction

sodium hydroxide

3,6-dichloropyridazine

meta-aminophenol

→

3-(6-chloro-3-pyridazinyloxy)benzeneamine

Solvants

dimethyl sulfoxide

Conditions de réaction

Traitement

1. 1
   TempératureThe stirred mixture was heated
2. 2
   Températurerefluxed (150°-155° C.) for two hours
3. 3
   Températurecooled
4. 4
   Filtrationfiltered
5. 5
   AutreThe filter cake was recrystallized from aqueous methanol

Mode opératoire

A concentrated aqueous solution of 44 g of sodium hydroxide was added to a stirred solution of 149 g of 3,6-dichloropyridazine and 114.5 g of meta-aminophenol in 500 ml of dimethyl sulfoxide, at room temperature. The stirred mixture was heated, refluxed (150°-155° C.) for two hours, cooled, and filtered. The filter cake was recrystallized from aqueous methanol to give 3-(6-chloro-3-pyridazinyloxy)benzeneamine (1A), as an off-white solid, mp: 76°-77° C.

Source