Réaction #95423

ord-5ad44d494bb24b35864f541e4bdd664b

Équation de réaction

CCCC(=O)c1cc2nc(CO)n(C)c2cc1Cl
5-butyryl-6-chloro-1-methyl-benzimidazole-2-methanol
[K+].[O]=[Mn](=[O])(=[O])[O-]
potassium permanganate
→
CCCC(=O)c1cc2nc(C(=O)O)n(C)c2cc1Cl
5-butyryl-6-chloro-1-methyl-benzimidazole-2-carboxylic acid

Réactifs

CCCC(=O)c1cc2nc(CO)n(C)c2cc1Cl
5-butyryl-6-chloro-1-methyl-benzimidazole-2-methanol
[K+].[O]=[Mn](=[O])(=[O])[O-]
potassium permanganate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In a manner analogous to that described in Example 12, 2.7 g of 5-butyryl-6-chloro-1-methyl-benzimidazole-2-methanol are oxidised with 2.5 g of potassium permanganate to give 5-butyryl-6-chloro-1-methyl-benzimidazole-2-carboxylic acid with a melting point of 90° (decomposition).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04344957uspto-grants-1982_08