Réaction #95276

Équation de réaction

sodium iodide

1-chloro-trans-1-octen 3-one

1-chloro-trans-1-octen-3-one

→

1-iodo-trans-1-octen-3-one

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONA mixture of 54.5 g
2. 2
   Températurerefluxed for 24 hours
3. 3
   TempératureThe reaction mixture is cooled
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated
6. 6
   AutreThe residue is partitioned between water and ether
7. 7
   LavageThe organic phase is washed with dilute sodium bicarbonate solution, brine
8. 8
   Séchagedried (MgSO4)
9. 9
   Autreevaporated to an oil
10. 10
    AutreThis material is used directly without purification

Mode opératoire

A mixture of 54.5 g. (0.364 mole) of sodium iodide and 40 g. (0.249 mole) of 1-chloro-trans-1-octen 3-one (Example 723) in 360 ml. of acetone is stirred and refluxed for 24 hours. The reaction mixture is cooled, filtered and concentrated. The residue is partitioned between water and ether. The organic phase is washed with dilute sodium bicarbonate solution, brine, dried (MgSO4) and evaporated to an oil. This material is used directly without purification.

Source