Réaction #949985

Équation de réaction

hydrochloric acid

sodium ethoxide

Diethyl 2-acetamidomalonate

docosyl bromide

→

diethyl 2-acetamido-2-docosylmalonate

Rendement 57.8%

Solvants

ethanol

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe mixture was refluxed for about 15 hours
2. 2
   Concentrationconcentrated
3. 3
   AutreThe concentrate was purified by silica gel column chromatography

Mode opératoire

Diethyl 2-acetamidomalonate (3.0 g) was dissolved in 50 ml of dry ethanol and 1.3 g of sodium ethoxide was added thereto. A solution of 6.5 g of docosyl bromide in 20 ml of dry ethanol was added thereto while stirring at room temperature. The inside of the reaction vessel was displaced with nitrogen and the mixture was refluxed for about 15 hours. The mixture was neutralized with a 1N aqueous hydrochloric acid solution and concentrated. The concentrate was purified by silica gel column chromatography to give 4.2 g of diethyl 2-acetamido-2-docosylmalonate.

Source